pentobarbital will decrease the extent or influence of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with powerful CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.overall health centers / slumber Middle/nembutal pentobarbital sodi